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  2. Mycobacterium tuberculosis topoisomerase I (MtTOP1) and Escherichia coli topoisomerase I have highly homologous transesterification domains, but the two enzymes have distinctly different C-terminal domains. To in...

    Authors: Gagandeep Narula, Jennifer Becker, Bokun Cheng, Neil Dani, Maria V Abrenica and Yuk-Ching Tse-Dinh

    Citation: BMC Biochemistry 2010 11:41

    Content type: Methodology article

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  3. Since chitin is a highly abundant natural biopolymer, many attempts have been made to convert this insoluble polysaccharide into commercially valuable products using chitinases and β-N-acetylglucosaminidases (Glc...

    Authors: Wipa Suginta, Duangkamon Chuenark, Mamiko Mizuhara and Tamo Fukamizo

    Citation: BMC Biochemistry 2010 11:40

    Content type: Research article

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  4. The LGI2 (leucine-rich, glioma inactivated 2) gene, a prime candidate for partial epilepsy with pericentral spikes, belongs to a family encoding secreted, beta-propeller domain proteins with EPTP/EAR epilepsy-...

    Authors: Vachiranee Limviphuvadh, Ling Ling Chua, Rabi 'Atul' Adawiyah Bte Rahim, Frank Eisenhaber, Sebastian Maurer-Stroh and Sharmila Adhikari

    Citation: BMC Biochemistry 2010 11:39

    Content type: Research article

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  5. Genes involved in hepatic metabolism have a sex-different expression in rodents. To test whether male and female rat livers differ regarding lipid and carbohydrate metabolism, whole-genome transcript profiles ...

    Authors: Carolina Gustavsson, Kamal Yassin, Erik Wahlström, Louisa Cheung, Johan Lindberg, Kerstin Brismar, Claes-Göran Östenson, Gunnar Norstedt and Petra Tollet-Egnell

    Citation: BMC Biochemistry 2010 11:38

    Content type: Research article

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  7. Proteinase-activated-receptor-2 (PAR2) is a seven transmembrane receptor that can activate two separate signaling arms: one through Gαq and Ca2+ mobilization, and a second through recruitment of β-arrestin scaffo...

    Authors: Ping Wang, Yong Jiang, Yinsheng Wang, John Y Shyy and Kathryn A DeFea

    Citation: BMC Biochemistry 2010 11:36

    Content type: Research article

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  8. Mycobacterium tuberculosis is a virulent bacillus causing tuberculosis, a disease responsible for million deaths each year worldwide. In order to understand its mechanism of pathogenesis in humans and to help con...

    Authors: Aejazur Rahman, Saumya S Srivastava, Amita Sneh, Neesar Ahmed and Musti V Krishnasastry

    Citation: BMC Biochemistry 2010 11:35

    Content type: Research article

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  9. Increasing our understanding of antibiotic resistance mechanisms is critical. To enable progress in this area, methods to rapidly identify and characterize antibiotic resistance conferring enzymes are required.

    Authors: Zhou Yu, Sean E Reichheld, Leslie Cuthbertson, Justin R Nodwell and Alan R Davidson

    Citation: BMC Biochemistry 2010 11:34

    Content type: Methodology article

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  10. Filamentous fungi in the genus Aspergillus produce a variety of natural products, including aflatoxin, the most potent naturally occurring carcinogen known. Aflatoxin biosynthesis, one of the most highly characte...

    Authors: Ludmila V Roze, Anindya Chanda, Maris Laivenieks, Randolph M Beaudry, Katherine A Artymovich, Anna V Koptina, Deena W Awad, Dina Valeeva, Arthur D Jones and John E Linz

    Citation: BMC Biochemistry 2010 11:33

    Content type: Research article

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  11. The diversity and function of ligninolytic genes in soil-inhabiting ascomycetes has not yet been elucidated, despite their possible role in plant litter decay processes. Among ascomycetes, Trichoderma reesei is a...

    Authors: Anthony Levasseur, Markku Saloheimo, David Navarro, Martina Andberg, Pierre Pontarotti, Kristiina Kruus and Eric Record

    Citation: BMC Biochemistry 2010 11:32

    Content type: Research article

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  12. Sulfhydryl oxidases are flavin-dependent enzymes that catalyse the formation of de novo disulfide bonds from free thiol groups, with the reduction of molecular oxygen to hydrogen peroxide. Sulfhydryl oxidases ...

    Authors: Greta Faccio, Kristiina Kruus, Johanna Buchert and Markku Saloheimo

    Citation: BMC Biochemistry 2010 11:31

    Content type: Research article

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  13. When cells are exposed to high salinity conditions, they develop a mechanism to extrude excess Na+ from cells to maintain the cytoplasmic Na+ concentration. Until now, the ATPase involved in Na+ transport in cyan...

    Authors: Kanteera Soontharapirakkul and Aran Incharoensakdi

    Citation: BMC Biochemistry 2010 11:30

    Content type: Research article

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  14. When eukaryotic cells are deprived of amino acids, uncharged tRNAs accumulate and activate the conserved GCN2 protein kinase. Activated Gcn2p up-regulates the general amino acid control pathway through phospho...

    Authors: John M Zaborske, Xiaochen Wu, Ronald C Wek and Tao Pan

    Citation: BMC Biochemistry 2010 11:29

    Content type: Research article

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  15. The β-carbonic anhydrase (CA, EC 4.2.1.1) enzymes have been reported in a variety of organisms, but their existence in animals has been unclear. The purpose of the present study was to perform extensive sequen...

    Authors: Leo Syrjänen, Martti Tolvanen, Mika Hilvo, Ayodeji Olatubosun, Alessio Innocenti, Andrea Scozzafava, Jenni Leppiniemi, Barbara Niederhauser, Vesa P Hytönen, Thomas A Gorr, Seppo Parkkila and Claudiu T Supuran

    Citation: BMC Biochemistry 2010 11:28

    Content type: Research article

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  18. Cysteine sulfenic acid (Cys-SOH) plays important roles in the redox regulation of numerous proteins. As a relatively unstable posttranslational protein modification it is difficult to quantify the degree to wh...

    Authors: Douglas S Rehder and Chad R Borges

    Citation: BMC Biochemistry 2010 11:25

    Content type: Research article

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  19. Sphaeroides Heme Protein (SHP) was discovered in the purple photosynthetic bacterium, Rhodobacter sphaeroides, and is the only known c-type heme protein that binds oxygen. Although initially not believed to be wi...

    Authors: Terry E Meyer, John A Kyndt and Michael A Cusanovich

    Citation: BMC Biochemistry 2010 11:24

    Content type: Research article

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  20. The expression of the drug-metabolizing enzyme cytochrome P450 3A4 (CYP3A4) is regulated by the pregnane × receptor (PXR), which is modulated by numerous signaling pathways, including the cyclin-dependent kina...

    Authors: Hanqing Dong, Wenwei Lin, Jing Wu and Taosheng Chen

    Citation: BMC Biochemistry 2010 11:23

    Content type: Research article

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  21. The archaeal exosome is formed by a hexameric RNase PH ring and three RNA binding subunits and has been shown to bind and degrade RNA in vitro. Despite extensive studies on the eukaryotic exosome and on the prote...

    Authors: Juliana S Luz, Celso RR Ramos, Márcia CT Santos, Patricia P Coltri, Fernando L Palhano, Debora Foguel, Nilson IT Zanchin and Carla C Oliveira

    Citation: BMC Biochemistry 2010 11:22

    Content type: Research article

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  22. Maltose-1-phosphate was detected in Mycobacterium bovis BCG extracts in the 1960's but a maltose-1-phosphate synthetase (maltokinase, Mak) was only much later purified from Actinoplanes missouriensis, allowing th...

    Authors: Vítor Mendes, Ana Maranha, Pedro Lamosa, Milton S da Costa and Nuno Empadinhas

    Citation: BMC Biochemistry 2010 11:21

    Content type: Research article

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  23. Although numerous non-radioactive methods are in use to measure the catalytic activity of protein kinases, most require specialized equipment and reagents and are not sufficiently sensitive for the detection o...

    Authors: Eva Lilienthal, Katharina Kolanowski and Walter Becker

    Citation: BMC Biochemistry 2010 11:20

    Content type: Methodology article

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  25. Activation of fatty acids by acyl-CoA synthetase enzymes is required for de novo lipid synthesis, fatty acid catabolism, and remodeling of biological membranes. Human long-chain acyl-CoA synthetase member 6, ASCL...

    Authors: Eric Soupene, Nghi Phuong Dinh, Melvin Siliakus and Frans A Kuypers

    Citation: BMC Biochemistry 2010 11:18

    Content type: Research article

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  26. The genome of the nematode Caenorhabditis elegans contains more than 30 putative globin genes that all are transcribed. Although their translated amino acid sequences fit the globin fold, a variety of amino-acid ...

    Authors: Eva Geuens, David Hoogewijs, Marco Nardini, Evi Vinck, Alessandra Pesce, Laurent Kiger, Angela Fago, Lesley Tilleman, Sasha De Henau, Michael C Marden, Roy E Weber, Sabine Van Doorslaer, Jacques Vanfleteren, Luc Moens, Martino Bolognesi and Sylvia Dewilde

    Citation: BMC Biochemistry 2010 11:17

    Content type: Research article

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  27. Unconjugated bilirubin (UCB) is an unstable substance with very low aqueous solubility. Its aqueous pKa values affect many of its interactions, particularly their pH-dependence. A companion paper shows that on...

    Authors: Pasupati Mukerjee and J Donald Ostrow

    Citation: BMC Biochemistry 2010 11:16

    Content type: Research article

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  28. Correct aqueous pKa values of unconjugated bilirubin (UCB), a poorly-soluble, unstable substance, are essential for understanding its functions. Our prior solvent partition studies, of unlabeled and [14C] UCB, in...

    Authors: Pasupati Mukerjee and J Donald Ostrow

    Citation: BMC Biochemistry 2010 11:15

    Content type: Research article

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  30. Microbial degradation of azo dyes is commonly initiated by the reduction of the azo bond(s) by a group of NADH or NADPH dependant azoreductases with many requiring flavin as a cofactor. In this study, we repor...

    Authors: Huizhong Chen, Jinhui Feng, Ohgew Kweon, Haiyan Xu and Carl E Cerniglia

    Citation: BMC Biochemistry 2010 11:13

    Content type: Research article

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  31. An important variability of contractile and metabolic properties between muscles has been highlighted. In the literature, the majority of studies on beef sensorial quality concerns M. longissimus thoracis. M. rec...

    Authors: Marie-Pierre Oury, Rollande Dumont, Catherine Jurie, Jean-François Hocquette and Brigitte Picard

    Citation: BMC Biochemistry 2010 11:12

    Content type: Research article

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  32. Natural rubber is a biopolymer with exceptional qualities that cannot be completely replaced using synthetic alternatives. Although several key enzymes in the rubber biosynthetic pathway have been isolated, ma...

    Authors: Thomas Schmidt, Malte Lenders, Andrea Hillebrand, Nicole van Deenen, Oliver Munt, Rudolf Reichelt, Wolfgang Eisenreich, Rainer Fischer, Dirk Prüfer and Christian Schulze Gronover

    Citation: BMC Biochemistry 2010 11:11

    Content type: Research article

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  33. Type four secretion systems (TFSS) are bacterial macromolecular transport systems responsible for transfer of various substrates such as proteins, DNA or protein-DNA complexes. TFSSs encode two or three ATPase...

    Authors: Ashraf Y Rangrez, Mohammad Y Abajy, Walter Keller, Yogesh Shouche and Elisabeth Grohmann

    Citation: BMC Biochemistry 2010 11:10

    Content type: Research article

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  34. Thiamine diphosphate (ThDP)-dependent enzymes form a vast and diverse class of proteins, catalyzing a wide variety of enzymatic reactions including the formation or cleavage of carbon-sulfur, carbon-oxygen, ca...

    Authors: Michael Widmann, Robert Radloff and Jürgen Pleiss

    Citation: BMC Biochemistry 2010 11:9

    Content type: Database

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  35. Orthophosphate recognition at allosteric binding sites is a key feature for the regulation of enzyme activity in mammalian glycogen phosphorylases. Protein residues co-ordinating orthophosphate in three bindin...

    Authors: Mario Mueller and Bernd Nidetzky

    Citation: BMC Biochemistry 2010 11:8

    Content type: Research article

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  36. Some functions of 4.1R in non-erythroid cells are directly related with its distinct sub-cellular localisation during cell cycle phases. During mitosis, 4.1R is implicated in cell cycle progression and spindle...

    Authors: Miguel A Treviño, Mar Rodríguez-Rodríguez, Isabel Correas, Miguel Marcilla, Juan P Albar, Manuel Rico, M Ángeles Jiménez and Marta Bruix

    Citation: BMC Biochemistry 2010 11:7

    Content type: Research article

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  37. Plant latex is the cytoplasm of highly specialized cells known as laticifers, and is thought to have a critical role in defense against herbivorous insects. Proteins abundantly accumulated in latex might there...

    Authors: Sakihito Kitajima, Kaeko Kamei, Shigeru Taketani, Masamitsu Yamaguchi, Fumiko Kawai, Aino Komatsu and Yoshihiro Inukai

    Citation: BMC Biochemistry 2010 11:6

    Content type: Research article

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  38. In the last ten years, deficiencies in tricarboxylic acid cycle (TCAC) enzymes have been shown to cause a wide spectrum of human diseases, including malignancies and neurological and cardiac diseases. A prereq...

    Authors: Sergio Goncalves, Vincent Paupe, Emmanuel P Dassa, Jean-Jacques Brière, Judith Favier, Anne-Paule Gimenez-Roqueplo, Paule Bénit and Pierre Rustin

    Citation: BMC Biochemistry 2010 11:5

    Content type: Methodology article

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  39. The phosphoethanolamine methyltransferase, PfPMT, of the human malaria parasite Plasmodium falciparum, a member of a newly identified family of phosphoethanolamine methyltransferases (PMT) found solely in some pr...

    Authors: April M Bobenchik, Jae-Yeon Choi, Arunima Mishra, Iulian N Rujan, Bing Hao, Dennis R Voelker, Jeffrey C Hoch and Choukri Ben Mamoun

    Citation: BMC Biochemistry 2010 11:4

    Content type: Research article

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  40. Protein-SH groups are amongst the most easily oxidized residues in proteins, but irreversible oxidation can be prevented by protein glutathionylation, in which protein-SH groups form mixed disulphides with glu...

    Authors: Darren Greetham, Jill Vickerstaff, Daniel Shenton, Gabriel G Perrone, Ian W Dawes and Chris M Grant

    Citation: BMC Biochemistry 2010 11:3

    Content type: Research article

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  41. Leptin is an adipocyte-derived hormone that acts via its hypothalamic receptor (LEPRb) to regulate energy balance. A downstream effect essential for the weight-regulatory action of leptin is the phosphorylatio...

    Authors: Holger Knobelspies, Julia Zeidler, Paul Hekerman, Simone Bamberg-Lemper and Walter Becker

    Citation: BMC Biochemistry 2010 11:2

    Content type: Research article

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  42. Phosphoenolpyruvate synthetase (PEPS; EC 2.7.9.2) catalyzes the synthesis of phosphoenolpyruvate from pyruvate in Escherichia coli when cells are grown on a three carbon source. It also catalyses the anabolic con...

    Authors: Jim N Burnell

    Citation: BMC Biochemistry 2010 11:1

    Content type: Research article

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  43. Estrogen receptor α (ERα) phosphorylation is important for estrogen-dependent transcription of ER-dependent genes, ligand-independent receptor activation and endocrine therapy response in breast cancer. Howeve...

    Authors: Christopher C Williams, Aninda Basu, Abeer El-Gharbawy, Latonya M Carrier, Carolyn L Smith and Brian G Rowan

    Citation: BMC Biochemistry 2009 10:36

    Content type: Research article

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  44. The Toc159 family of proteins serve as receptors for chloroplast-destined preproteins. They directly bind to transit peptides, and exhibit preprotein substrate selectivity conferred by an unknown mechanism. Th...

    Authors: Lynn GL Richardson, Masoud Jelokhani-Niaraki and Matthew D Smith

    Citation: BMC Biochemistry 2009 10:35

    Content type: Research article

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  45. We have previously identified endonuclein as a cell cycle regulated WD-repeat protein that is up-regulated in adenocarcinoma of the pancreas. Now, we aim to investigate its biomedical functions.

    Authors: Maja Ludvigsen, Morten Østergaard, Henrik Vorum, Christian Jacobsen and Bent Honoré

    Citation: BMC Biochemistry 2009 10:34

    Content type: Research article

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  46. FGFRL1, the gene for the fifth member of the fibroblast growth factor receptor (FGFR) family, is found in all vertebrates from fish to man and in the cephalochordate amphioxus. Since it does not occur in more ...

    Authors: Lei Zhuang, Andrei V Karotki, Philip Bruecker and Beat Trueb

    Citation: BMC Biochemistry 2009 10:33

    Content type: Research article

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  48. β-carotene 15,15'-monooxygenase (BCMO1) catalyzes the crucial first step in vitamin A biosynthesis in animals. We wished to explore the possibility that a carbocation intermediate is formed during the cleavage...

    Authors: Eugenia Poliakov, Susan Gentleman, Preethi Chander, Francis X Cunningham Jr, Bella L Grigorenko, Alexander V Nemuhin and T Michael Redmond

    Citation: BMC Biochemistry 2009 10:31

    Content type: Research article

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  49. Ghrelin (GRLN) is now known to be an appetite-stimulating and growth hormone (GH)-releasing peptide that is predominantly synthesized and secreted from the stomachs of various vertebrate species from fish to m...

    Authors: Hiroyuki Kaiya, Shiho Kodama, Koutaro Ishiguro, Kouhei Matsuda, Minoru Uchiyama, Mikiya Miyazato and Kenji Kangawa

    Citation: BMC Biochemistry 2009 10:30

    Content type: Research article

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  50. Molecular mechanisms underlying prion agent replication, converting host-encoded cellular prion protein (PrPC) into the scrapie associated isoform (PrPSc), are poorly understood. Selective self-interaction betwee...

    Authors: Alan Rigter, Jan Priem, Drophatie Timmers-Parohi, Jan PM Langeveld, Fred G van Zijderveld and Alex Bossers

    Citation: BMC Biochemistry 2009 10:29

    Content type: Research article

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BMC Biochemistry

ISSN: 1471-2091

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